evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

5 questions · 5 findings · 1 reviews · Common Mental Disorders

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 1 · 20%GRADE not reported 0 · 0%Very low 1 · 20%Low 3 · 60%Moderate 0 · 0%High 0 · 0%

Valproate vs RISPERIDONE

Response rate at 8 weeks (primary efficacy outcome) · Children and adolescents with acute mania

Valproate may leads to lower response rate at 8 weeks (primary efficacy outcome) compared with risperidone (low certainty).

1 finding from 1 review

Valproate vs RISPERIDONE

Number of participants with any adverse event (primary tolerability outcome) · Children and adolescents with acute mania

The review found no eligible studies for this question.

1 finding from 1 review

Valproate vs RISPERIDONE

Adverse effects: 1. Sedation · Children and adolescents with acute mania

It is very uncertain whether valproate changes adverse events ‐ Sedation At 8 weeks (secondary tolerability outcome) compared with risperidone (very low certainty).

1 finding from 1 review

Valproate vs RISPERIDONE

Change in symptom severity at 5 ‐ 12 weeks (secondary efficacy outcome) · Children and adolescents with acute mania
1 finding from 1 review

Valproate vs RISPERIDONE

Dropout · Children and adolescents with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause (secondary acceptability outcome) At 5 ‐ 12… compared with risperidone (low certainty).

1 finding from 1 review