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What do systematic reviews say?

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Evidence found and GRADE certainty

2 questions · 2 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 0 · 0%Moderate 1 · 50%High 0 · 0%

Valproate vs lithium

Response rate at 3 weeks (primary efficacy outcome) · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in response rate at 3 weeks (primary efficacy outcome) compared with lithium (moderate certainty).

1 finding from 1 review

Valproate vs lithium

Response rate at 8 weeks (primary efficacy outcome) · Children and adolescents with acute mania

It is very uncertain whether valproate changes response rate at 8 weeks (primary efficacy outcome) compared with lithium (very low certainty).

1 finding from 1 review