Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

No studies found 1 · 50%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

Number of participants with any adverse event (primary tolerability outcome) · Children and adolescents with acute mania

The review found no eligible studies for this question.

1 finding from 1 review

Valproate for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Primary outcome 3: Adverse events · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in number of participants with any adverse event at 2‐4 weeks (primary… compared with lithium (low certainty).

1 finding from 1 review

Valproate for acute mania 2019 · Cochrane Headline outcomes only
OR 0.61 [0.25, 1.5]
2 studies · 164 participants
Low