Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 2 · 33.3%Moderate 2 · 33.3%High 1 · 16.7%

Valproate vs lithium

Dropout · Children and adolescents with acute mania

It is very uncertain whether valproate changes dropout rate ‐ All‐cause At 8 weeks (secondary acceptability outcome) compared with lithium (very low certainty).

1 finding from 1 review

Valproate vs placebo

Dropout · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause 3‐8 weeks (secondary acceptability outcome) compared with placebo (moderate certainty).

1 finding from 1 review

Valproate vs placebo

Dropout · Children and adolescents with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause At 4‐6 weeks (secondary acceptability… compared with placebo (low certainty).

1 finding from 1 review

Valproate vs lithium

Dropout · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause At 2‐4 weeks (secondary acceptability… compared with lithium (moderate certainty).

1 finding from 1 review

Valproate vs OLANZAPINE

Dropout · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause At 3‐12 weeks (secondary acceptability… compared with olanzapine (high certainty).

1 finding from 1 review

Valproate vs RISPERIDONE

Dropout · Children and adolescents with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause (secondary acceptability outcome) At 5 ‐ 12… compared with risperidone (low certainty).

1 finding from 1 review