Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Kidney and Transplant

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 2 · 28.6%High 0 · 0%

CMV disease · solid organ transplant recipients

Valaciclovir showed no clear difference in CMV disease compared with ganciclovir or valganciclovir (low certainty).

1 finding from 1 review

All‐cause death · solid organ transplant recipients

Valaciclovir showed no clear difference in all‐cause death compared with ganciclovir or valganciclovir (low certainty).

1 finding from 1 review

CMV infection · solid organ transplant recipients

Valaciclovir showed no clear difference in CMV infection compared with ganciclovir or valganciclovir (low certainty).

1 finding from 1 review

Acute rejection · solid organ transplant recipients

It is very uncertain whether valaciclovir changes acute rejection compared with ganciclovir or valganciclovir (very low certainty).

1 finding from 1 review

Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients 2024 · Cochrane Headline outcomes only
RR 0.91 [0.22, 3.73]
3 studies · 271 participants
Very low

Graft loss · solid organ transplant recipients

Valaciclovir showed no clear difference in graft loss compared with ganciclovir or valganciclovir (low certainty).

1 finding from 1 review

Leucopenia · solid organ transplant recipients

Valaciclovir showed no clear difference in leucopenia compared with ganciclovir or valganciclovir (moderate certainty).

1 finding from 1 review

Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients 2024 · Cochrane Headline outcomes only
RR 0.74 [0.45, 1.24]
2 studies · 188 participants
Moderate

SCr at the end of · solid organ transplant recipients

1 finding from 1 review

Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients 2024 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 271 participants
Moderate