Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews

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No studies found 5 · 62.5%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 1 · 12.5%Moderate 1 · 12.5%High 0 · 0%

Two doses of HPV vaccine vs three doses of HPV vaccine

Clinical and harms outcomes* · 9‐ to 15‐year‐old females

The review found no eligible studies for this question.

1 finding from 1 review

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Two doses of HPV vaccine vs three doses of HPV vaccine

Antibody response (immunogenicity) · 9‐ to 15‐year‐old females

Two doses of HPV vaccine probably leads to lower antibody response (immunogenicity) compared with three doses of HPV vaccine (moderate certainty).

1 finding from 1 review

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related… 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 45 participants
Moderate

Two doses of HPV vaccine vs three doses of HPV vaccine

High‐grade cervical intraepithelial neoplasia, adenocarcinoma in situ, and cervical cancer · 9‐ to 15‐year‐old females

The review found no eligible studies for this question.

1 finding from 1 review

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Two doses of HPV vaccine vs three doses of HPV vaccine

High‐grade cervical, vulval, and vaginal disease · 9‐ to 15‐year‐old females

The review found no eligible studies for this question.

1 finding from 1 review

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Two doses of HPV vaccine vs three doses of HPV vaccine

Overall local/injection site adverse events · 9‐ to 15‐year‐old females

The review found no eligible studies for this question.

1 finding from 1 review

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Two doses of HPV vaccine vs three doses of HPV vaccine

Overall systemic events and general symptoms · 9‐ to 15‐year‐old females

The review found no eligible studies for this question.

1 finding from 1 review

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Two doses of HPV vaccine vs three doses of HPV vaccine

Serious adverse events at up to 5‐year · 9‐ to 15‐year‐old females

It is very uncertain whether two doses of HPV vaccine changes serious adverse events at up to 5‐year compared with three doses of HPV vaccine (very low certainty).

1 finding from 1 review

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related… 2019 · Cochrane Headline outcomes only
OR 1.03 [0.64, 1.66]
4 studies · 2317 participants
Very low

Two doses of HPV vaccine vs three doses of HPV vaccine

Mortality at up to 5‐year · 9‐ to 15‐year‐old females

Two doses of HPV vaccine showed no clear difference in mortality at up to 5‐year compared with three doses of HPV vaccine (low certainty).

1 finding from 1 review

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related… 2019 · Cochrane Headline outcomes only
OR 0.33 [0.01, 8.19]
3 studies · 1797 participants
Low