The review found no eligible studies for this question.
Triple therapy may leads to lower moderate‐to‐severe exacerbations (rate) compared with LABA/LAMA combination (low certainty).
Triple therapy may leads to lower severe exacerbations (rate) compared with LABA/LAMA combination (low certainty).
Triple therapy leads to higher respiratory HRQoL measured by SGRQ, ≥ 4‐point decrease from baseline… compared with LABA/LAMA combination (high certainty).
Triple therapy probably leads to higher pneumonia (labelled as an SAE) compared with LABA/LAMA combination (moderate certainty).
Triple therapy showed no clear difference in all‐cause SAEs compared with LABA/LAMA combination (low certainty).
Triple therapy probably leads to higher symptom score TDI, ≥ 1‐unit increase (lower scores indicate worse… compared with LABA/LAMA combination (moderate certainty).
Triple therapy may leads to higher lung function, change in trough FEV1 (mL) compared with LABA/LAMA combination (low certainty).
Triple therapy may leads to lower mortality (all‐cause) compared with LABA/LAMA combination (low certainty).