What do systematic reviews say?

Triple therapy vs LABA/LAMA combination

Triple therapy probably leads to higher pneumonia (labelled as an SAE) compared with LABA/LAMA combination (moderate certainty).

• Inhaled corticosteroids with combination inhaled long‐acting beta2‐agonists and long‐acting muscarinic antagonists for… 2023 · Cochrane Headline outcomes only
  OR 1.74 [1.39, 2.18]
  4 studies · 15412 participants
  Moderate