Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Airways

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 4 · 57.1%High 0 · 0%

Treatment route: intravenous corticosteroid vs oral corticosteroid

Mortality after discharge (1‐3 months) · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in mortality after discharge (1‐3 months) compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
OR 1.4 [0.44, 4.51]
3 studies · 298 participants
Moderate

Treatment route: intravenous corticosteroid vs oral corticosteroid

Length of hospitalisation (days) · exacerbations of COPD

1 finding from 1 review

Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 298 participants
Low

Treatment route: intravenous corticosteroid vs oral corticosteroid

Adverse drug effect—hyperglycaemia · exacerbations of COPD

Treatment route: intravenous corticosteroid probably leads to higher adverse drug effect ‐ hyperglycaemia compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
OR 4.89 [1.2, 19.94]
1 study · 40 participants
Moderate

Treatment route: intravenous corticosteroid vs oral corticosteroid

Arterial blood gas tension: PaO2 after 3 months mmHg · exacerbations of COPD

1 finding from 1 review

Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Treatment route: intravenous corticosteroid vs oral corticosteroid

Treatment failure Need for additional treatment · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in treatment failure Need to intensify therapy compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
OR 0.67 [0.34, 1.3]
3 studies · 298 participants
Moderate

Treatment route: intravenous corticosteroid vs oral corticosteroid

Relapse Hospital readmission for COPD · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in relapse Hospital readmission for COPD compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
OR 0.95 [0.5, 1.8]
3 studies · 298 participants
Moderate

Treatment route: intravenous corticosteroid vs oral corticosteroid

Breathlessness ‐ early effect VAS 0‐10. Scale from: 0 to 10. · exacerbations of COPD

1 finding from 1 review

Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 75 participants
Low