Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs placebo

Myocardial infarction (0 to 30 days) · people undergoing definitive fixation of hip, pelvic and long bone fractures

It is very uncertain whether topical tranexamic acid changes risk of myocardial infarction (30 days post‐surgery) compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or joint… 2023 · Cochrane Headline outcomes only
Peto OR 0.15 [0, 7.62]
1 study · 36 participants
Very low

Intravenous tranexamic acid vs placebo

Myocardial infarction (0 to 30 days) · people undergoing definitive fixation of hip, pelvic and long bone fractures

Intravenous tranexamic acid showed no clear difference in risk of myocardial infarction (30 days post‐surgery) compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or joint… 2023 · Cochrane Headline outcomes only
RD 0
2 studies · 199 participants
Low