Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 2 · 50%Moderate 1 · 25%High 0 · 0%

Tramadol vs paracetamol

Withdrawals due to adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants who withdrew due to adverse events compared with acetaminophen (very low certainty).

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
RR 5 [0.27, 92.62]
1 study · 20 participants
Very low

Tramadol vs NSAIDs

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol alone may leads to higher number of participants who withdrew due to adverse events compared with NSAIDs (low certainty).

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
RR 1.88 [1.27, 2.76]
2 studies · 929 participants
Low

Tramadol vs other opioids

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol alone may leads to higher number of participants who withdrew due to adverse events compared with other opioids (low certainty).

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
RR 2.26 [1.52, 3.37]
3 studies · 438 participants
Low

Tramadol vs placebo

Withdrawals due to adverse events · Patients with osteoarthritis of the knee or hip

Tramadol alone probably leads to higher number of participants who withdrew due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
RR 2.64 [2.17, 3.2]
9 studies · 4533 participants
Moderate