What do systematic reviews say?

Bilateral extraction of compromised mandibular first permanent molars vs Age- and gender-matched non-extraction controls

Bilateral lower first permanent molar extraction was associated with counter-clockwise rotation of the occlusal plane and a mild decrease in lower anterior face height in one case-control study; ungraded.

• Consequences of early extraction of compromised first permanent molar: a systematic review. 2018 All outcomes

  Private clinics (Brazil)
  Normando and Cavacami: decreased GnSN angle (P = 0.05), counter-clockwise rotation of the occlusal plane (mean 5.6 vs 12.6 degrees, P = 0.0001), and decreased lower anterior face height (P = 0.048). Table 3: Category…
  1 study
  GRADE not reported

Extraction of the primary maxillary canine plus cervical pull headgear vs Extraction of the primary maxillary canine alone

• Extraction of primary (baby) teeth for unerupted palatally displaced permanent canine teeth in children 2012 · Cochrane All outcomes

  At least 6 months follow-up after the intervention
  Narrative (not pooled, not GRADE-rated). Leonardi 2004: extraction plus headgear (80%) gave significantly higher eruption than extraction alone (50%) (Chi2 4.69; P<0.05). Baccetti 2008: extraction plus headgear was…
  2 studies · 79 participants
  GRADE not reported

Any surgical or non-surgical technique or material used for the treatment of post-extraction bleeding vs Placebo, no treatment, or another active antifungal intervention

The review found no eligible studies for this question.

• Interventions for treating post‐extraction bleeding 2018 · Cochrane All outcomes
  No data are available as no RCTs have been conducted on interventions to treat post-extraction bleeding
  0 studies
  No studies found

Any surgical or non-surgical technique or material used for the treatment of post-extraction bleeding vs Placebo, no treatment, or another active antifungal intervention

The review found no eligible studies for this question.

• Interventions for treating post‐extraction bleeding 2018 · Cochrane All outcomes
  No data are available as no RCTs have been conducted on interventions to treat post-extraction bleeding
  0 studies
  No studies found

Any surgical or non-surgical technique or material used for the treatment of post-extraction bleeding vs Placebo, no treatment, or another active antifungal intervention

The review found no eligible studies for this question.

• Interventions for treating post‐extraction bleeding 2018 · Cochrane All outcomes
  No data are available as no RCTs have been conducted on interventions to treat post-extraction bleeding
  0 studies
  No studies found

Any surgical or non-surgical technique or material used for the treatment of post-extraction bleeding vs Placebo, no treatment, or another active antifungal intervention

The review found no eligible studies for this question.

• Interventions for treating post‐extraction bleeding 2018 · Cochrane All outcomes
  No data are available as no RCTs have been conducted on interventions to treat post-extraction bleeding
  0 studies
  No studies found

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Systemic antibiotic prophylaxis (any regimen; topical therapy… may leads to lower dry socket compared with placebo (low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  1st to 7th day
  RR 0.66 [0.45, 0.97]
  13 studies · 1882 participants
  Low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Systemic antibiotic prophylaxis (any regimen; topical therapy… may leads to lower postsurgical infectious complications compared with placebo (low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  1st to 14th day
  RR 0.34 [0.19, 0.64]
  12 studies · 1728 participants
  Low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes swelling (7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  7th day
  RR 0.80 [0.50, 1.27]
  4 studies · 452 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes pain (continuous, VAS 0-10 cm, 7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  6th to 7th day
  MD -0.26 [-0.59, 0.07]
  4 studies · 422 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes presence of pain (dichotomous, yes/no on 6th-7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  6th to 7th day
  RR 0.59 [0.31, 1.12]
  3 studies · 675 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes adverse effects compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  1st to 7th day
  RR 1.46 [0.81, 2.64]
  8 studies · 1277 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes trismus (dichotomous, 7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  7th day
  RR 0.77 [0.42, 1.41]
  3 studies · 199 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs Placebo

The review found no eligible studies for this question.

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes
  No studies: none of the 23 included trials evaluated tooth extraction in immunocompromised patients; subgroup analysis based on immune status was not possible as no such studies were identified.
  0 studies
  No studies found

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes fever (6th-7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  6th to 7th day
  RR 0.66 [0.24, 1.79]
  4 studies · 475 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs Placebo

The review found no eligible studies for this question.

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes
  No studies in general dental practice for removal of decayed teeth. PUB3 added one routine intra-alveolar extraction trial and one complex oral surgery trial (2 of 23 non-third-molar), but the single intra-alveolar…
  0 studies
  No studies found

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

It is very uncertain whether maxillary distraction osteogenesis changes long-term skeletal relapse/stability (horizontal movement of A-point) compared with orthognathic surgery (conventional Le Fort I osteotomy) (very low certainty).

• Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients 2018 · Cochrane All outcomes

  5 years (long-term)
  MD 4.80 [0.41, 9.19]
  1 study · 16 participants
  Very low

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

It is very uncertain whether maxillary distraction osteogenesis changes speech: resonance (hypernasality) (deterioration/improvement) compared with orthognathic surgery (conventional Le Fort I osteotomy) (very low certainty).

• Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients 2018 · Cochrane All outcomes

  17 months (mean)
  RR 0.11 [0.01, 1.85]
  1 study · 22 participants
  Very low

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

• Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients 2018 · Cochrane All outcomes

  12 months
  SoF (Very Low): Clinical morbidities assessed with questionnaires, follow-up 12 months; risk with orthognathic surgery 3/14; risk with maxillary distraction osteogenesis 3/15; relative effect -; 29 participants (1…
  1 study · 29 participants
  Very low

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

• Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients 2018 · Cochrane All outcomes

  up to 2 years (significant at 3 months)
  Results text (Ungraded; not in SoF): social self-esteem (subset of the Culture-Free Self-Esteem Inventory, CFSEI) - DO participants had lower social self-esteem in the first three months postoperatively, with a…
  1 study · 30 participants
  GRADE not reported