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Evidence found and GRADE certainty

4 questions · 4 findings · 1 reviews · Common Mental Disorders

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No studies found 3 · 75%GRADE not reported 0 · 0%Very low 1 · 25%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Topiramate as add‐on therapy vs alternative drug

Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Topiramate as add‐on therapy vs alternative drug

Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Topiramate as add‐on therapy vs alternative drug

> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder

It is very uncertain whether topiramate as add‐on therapy changes response to treatment with topiramate. Number of participants… compared with alternative drug (very low certainty).

1 finding from 1 review