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Evidence found and GRADE certainty

11 questions · 11 findings · 2 reviews · Epilepsy

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 18.2%Low 1 · 9.1%Moderate 4 · 36.4%High 4 · 36.4%

Topiramate vs carbamazepine

Time to treatment failure (any reason related to treatment) All participants ‐ adjusted by seizure type Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to treatment failure (any reason related to treatment) All… compared with carbamazepine (moderate certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate probably leads to higher time to treatment failure (any reason related to treatment)Subgroup:… compared with carbamazepine (moderate certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to treatment failure (any reason related to treatment) Subgroup: generalised onset tonic‐clonic seizures or unclassified epilepsy Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to treatment failure (any reason related to treatment)… compared with carbamazepine (low certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to first seizure (post‐randomisation) All participants Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to first seizure after randomisation All participants Range of compared with carbamazepine (high certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to first seizure after randomisation Subgroup: focal onset… compared with carbamazepine (high certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to first seizure after randomisation Subgroup: generalised onset tonic‐clonic seizures or unclassified epilepsy Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to first seizure after randomisation Subgroup: generalised… compared with carbamazepine (moderate certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to 12‐month remission ‐ all participants Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate leads to lower time to 12‐month remission of seizures All participants Range of compared with carbamazepine (high certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to achieve 12‐month remission (seizure‐free period) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate leads to lower time to 12‐month remission of seizures Subgroup: focal onset… compared with carbamazepine (high certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to 12‐month remission of seizures Subgroup: generalised onset tonic‐clonic seizures or unclassified epilepsy Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to 12‐month remission of seizures Subgroup: generalised onset… compared with carbamazepine (moderate certainty).

1 finding from 1 review