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Evidence found and GRADE certainty

3 questions · 3 findings · 1 reviews · Oral medicine and oral cancer

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No studies found 0 · 0%GRADE not reported 1 · 33.3%Very low 2 · 66.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Topical treatments (topical urea 10%) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    short-term (up to 3 months) · topical urea 10%
    Topical urea 10% (Alvarenga da Silva 2014) contributes to the topical treatments short-term symptom-relief comparison (insufficient/contradictory); no separate estimate reported.
    1 study · 38 participants
    GRADE not reported

Topical treatments (topical urea 10%) vs placebo

Change in feeling of dryness · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    short-term (up to 3 months) · topical urea 10%
    SoF9. Change in feeling of dryness short-term (xerostomia questionnaire, 1-5, lower better): single study narratively reported no difference before or after treatment; 38 participants (1 RCT, topical urea); very low.
    1 study · 38 participants
    Very low

Topical treatments (topical urea 10%) vs placebo

Change in taste · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    short-term (up to 3 months) · topical urea 10%
    SoF9. Change in taste short-term (Quantitative Sensory Testing gustative threshold): single study narratively reported no difference in short-term gustation thresholds; 38 participants (1 RCT, topical urea); very low.
    1 study · 38 participants
    Very low