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What do systematic reviews say?

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Evidence found and GRADE certainty

23 questions · 24 findings · 2 reviews

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No studies found 2 · 8.3%GRADE not reported 0 · 0%Very low 8 · 33.3%Low 10 · 41.7%Moderate 3 · 12.5%High 1 · 4.2%

Topical plus systemic prophylaxis vs placebo or no treatment

Dropouts due to adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis showed no clear difference in dropouts due to adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review

Topical plus systemic prophylaxis vs placebo or no treatment

Gastrointestinal adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis showed no clear difference in gastrointestinal adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review

Topical plus systemic prophylaxis vs placebo or no treatment

Allergic adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis showed no clear difference in allergic adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review