What do systematic reviews say?

Three doses HPV vaccine vs control

Three doses HPV vaccine probably leads to lower external genital lesions (any genotype) at up to 3‐year compared with control (moderate certainty).

• Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related… 2019 · Cochrane Headline outcomes only
  Rate ratio 0.16 [0.07, 0.38]
  1 study · 2545 participants
  Moderate