What do systematic reviews say?

Tailoring asthma treatment using FeNO vs clinical symptoms

Tailoring asthma treatment using fractional exhaled nitric oxide probably leads to lower number of participants who had ≥ 1 exacerbations over study period… compared with clinical symptoms (moderate certainty).

• Exhaled nitric oxide levels to guide treatment for children with asthma 2016 · Cochrane Headline outcomes only
  OR 0.62 [0.49, 0.8]
  8 studies · 1279 participants
  Moderate

Tailoring asthma treatment using FeNO vs clinical symptoms

It is very uncertain whether tailoring asthma treatment using fractional exhaled nitric oxide changes number of asthma exacerbations per 52 weeks (exacerbation rate) compared with clinical symptoms (very low certainty).

• Exhaled nitric oxide levels to guide treatment for children with asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 736 participants
  Very low

Tailoring asthma treatment using FeNO vs clinical symptoms

• Exhaled nitric oxide levels to guide treatment for children with asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 317 participants
  Moderate