Findings

What do systematic reviews say?

13 questions · 33 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 33 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

CT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT genotype vs CC genotype of AMELX rs946252 and dental caries susceptibility (CT vs CC model: OR 2.80, 95% CI 0.93-8.43) in the Ethnicity: Caucasian subgroup; certainty not graded.

6 findings from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Caucasian
OR 2.80 [0.93, 8.43]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Low caries
OR 0.95 [0.40, 2.25]
1 study
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Mixed
OR 0.95 [0.40, 2.25]
1 study
GRADE not reported

Show 3 more findings

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Overall
OR 1.45 [0.75, 2.81]
3 studies · 298 participants
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Caries-free
OR 2.80 [0.93, 8.43]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Age group: Children
OR 1.24 [0.61, 2.49]
2 studies
GRADE not reported

TT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC genotype of AMELX rs946252 and dental caries susceptibility (TT vs CC model: OR 1.54, 95% CI 0.61-3.92) in the Age group: Children subgroup; certainty not graded.

6 findings from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Age group: Children
OR 1.54 [0.61, 3.92]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Overall
OR 1.27 [0.58, 2.75]
3 studies · 298 participants
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Caries-free
OR 1.42 [0.54, 3.76]
2 studies
GRADE not reported

Show 3 more findings

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Low caries
OR 1.03 [0.28, 3.75]
1 study
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Caucasian
OR 1.42 [0.54, 3.76]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Mixed
OR 1.03 [0.28, 3.75]
1 study
GRADE not reported

TT genotype of AMELX rs946252 vs CC + CT genotype

Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls

The pooled odds ratio was 0.73 (95% CI 0.19 to 2.87).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Caucasian (n=2)
OR 0.73 [0.19, 2.87]
2 studies
GRADE not reported

TT genotype of AMELX rs946252 vs CC + CT genotype of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC + CT genotype of AMELX rs946252 and dental caries susceptibility (TT vs CC + CT model: OR 0.73, 95% CI 0.19-2.87) in the Control group: Caries-free subgroup; certainty not graded.

6 findings from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Caries-free
OR 0.73 [0.19, 2.87]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Age group: Children
OR 1.26 [0.56, 2.83]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Overall
OR 0.82 [0.43, 1.56]
3 studies · 298 participants
GRADE not reported

Show 3 more findings

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Caucasian
OR 0.73 [0.19, 2.87]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Low caries
OR 1.04 [0.29, 3.75]
1 study
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Mixed
OR 1.04 [0.29, 3.75]
1 study
GRADE not reported

TT genotype of AMELX rs946252 vs CC genotype

Dental caries susceptibility · Ethnicity: Mixed (n=1) individuals with caries/high caries and controls

The pooled odds ratio was 1.03 (95% CI 0.28 to 3.75).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Mixed (n=1)
OR 1.03 [0.28, 3.75]
1 study
GRADE not reported

TT genotype of AMELX rs946252 vs CC genotype

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The pooled odds ratio was 1.03 (95% CI 0.28 to 3.75).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Control group: Low caries (n=1)
OR 1.03 [0.28, 3.75]
1 study
GRADE not reported

CT genotype of AMELX rs946252 vs CC genotype

Dental caries susceptibility · Ethnicity: Mixed (n=1) individuals with caries/high caries and controls

The pooled odds ratio was 0.95 (95% CI 0.40 to 2.25).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Mixed (n=1)
OR 0.95 [0.40, 2.25]
1 study
GRADE not reported

CT genotype of AMELX rs946252 vs CC genotype

Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls

The pooled odds ratio was 2.80 (95% CI 0.93 to 8.43).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Caucasian (n=2)
OR 2.80 [0.93, 8.43]
2 studies
GRADE not reported

TT genotype of AMELX rs946252 vs CC + CT genotype

Dental caries susceptibility · Ethnicity: Mixed (n=1) individuals with caries/high caries and controls

The pooled odds ratio was 1.04 (95% CI 0.29 to 3.75).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Mixed (n=1)
OR 1.04 [0.29, 3.75]
1 study
GRADE not reported

TT genotype of AMELX rs946252 vs CC genotype

Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls

The pooled odds ratio was 1.42 (95% CI 0.54 to 3.76).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Caucasian (n=2)
OR 1.42 [0.54, 3.76]
2 studies
GRADE not reported

CT + TT genotype (T-allele carriers) of AMELX rs946252 vs CC genotype

Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls

The pooled odds ratio was 1.63 (95% CI 0.67 to 4.01).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Caucasian (n=2)
OR 1.63 [0.67, 4.01]
2 studies
GRADE not reported

CT + TT genotype (T-allele carriers) of AMELX rs946252 vs CC genotype

Dental caries susceptibility · Ethnicity: Mixed (n=1) individuals with caries/high caries and controls

The pooled odds ratio was 0.98 (95% CI 0.46 to 2.07).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Mixed (n=1)
OR 0.98 [0.46, 2.07]
1 study
GRADE not reported

CT + TT genotype (T-allele carriers) of AMELX rs946252 vs CC genotype of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs946252 and dental caries susceptibility (CT + TT vs CC model: OR 1.63, 95% CI 0.67-4.01) in the Ethnicity: Caucasian subgroup; certainty not graded.

6 findings from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Caucasian
OR 1.63 [0.67, 4.01]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Age group: Children
OR 1.24 [0.66, 2.33]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Overall
OR 1.21 [0.68, 2.14]
3 studies · 298 participants
GRADE not reported

Show 3 more findings

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Caries-free
OR 1.63 [0.67, 4.01]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Mixed
OR 0.98 [0.46, 2.07]
1 study
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Low caries
OR 0.98 [0.46, 2.07]
1 study
GRADE not reported