Effects of non-stevia high-intensity sweeteners (aspartame, sucralose, saccharin) on cariogenic bacteria in dental plaque or saliva · healthy people
No eligible studies evaluated high-intensity sweeteners such as aspartame, sucralose, or saccharin for their effect on cariogenic bacteria.
1 finding from 1 review
Change in Mutans streptococci (MS) count in saliva · healthy people
Xylitol and sorbitol did not differ significantly for Mutans streptococci in saliva (SMD -0.16, 95% CI -0.44 to 0.12; 2 trials, P=.25); not GRADE-rated.
1 finding from 1 review
Change in Mutans streptococci (MS) count in dental plaque · healthy people
Xylitol reduced Mutans streptococci in dental plaque more than sorbitol (SMD -0.45, 95% CI -0.69 to -0.21; 4 trials, I2=7%); not GRADE-rated.
1 finding from 1 review
Intensity modulated radiotherapy (IMRT) vs Conventional or other radiotherapy
Outcome not reported · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
The review found no eligible studies for this question.
1 finding from 1 review
Change in Mutans streptococci (MS) and Lactobacilli in saliva · Schoolchildren (6-9 years), high caries risk
The single stevia trial (Cocco 2019) reported a significant reduction in salivary Mutans streptococci and lactobacilli, but gave no effect size and was not GRADE-rated.
1 finding from 1 review
Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis. 2024 All outcomes42 days · Schoolchildren in Italy, high caries risk; sweetener delivered as a daily snack · Single study (Cocco 2019); not pooled
Cocco 2019 (the only high-intensity sweetener trial): the stevia snack showed a significant decrease in MS (P < .01) and in lactobacilli (P = .03) versus baseline, whereas the white-sugar snack showed no significant…
1 study · 271 participants
GRADE not reported
Change in Mutans streptococci (MS) count in dental plaque · healthy people
Xylitol significantly reduced Mutans streptococci in dental plaque compared with no treatment (SMD -0.73, 95% CI -1.09 to -0.37; 5 trials, I2=53%; not GRADE-rated).
1 finding from 1 review
Projected Significant Caries (SiC) index · Alaska Native children (below age 18)
A simulation projected a 50% drop in the Significant Caries index for children (12.3 to 6.1) under the PDHA model (certainty not graded).
2 findings from 1 review
Projected proportion of caries-free children (5-18 years) · Alaska Native children (below age 18)
A simulation projected 0% of children aged 5-18 would be caries-free under the baseline scenario (certainty not graded).
3 findings from 1 review
Projected receipt of school-based prevention services · Alaska Native children (below age 18)
A simulation projected that over 90% of children would receive school-based prevention services under the PDHA model, up from 53% (certainty not graded).
1 finding from 1 review
Projected dental care utilisation · Alaska Native children (below age 18)
A simulation projected that the PDHA program would raise dental care utilisation from 75% to 90% (certainty not graded).
1 finding from 1 review
Projected mean DMFT (children below 5 years) · Alaska Native children (below age 18)
A simulation projected mean DMFT in children under 5 would fall from 7.4 to 4.9 under the PDHA model (certainty not graded).
1 finding from 1 review