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Evidence found and GRADE certainty

5 questions · 5 findings · 1 reviews · Periodontology

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No studies found 0 · 0%GRADE not reported 5 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Systemic oral acyclovir vs placebo or no treatment

Duration and time of healing of intraoral (oral) lesions; number of individuals with oral lesions · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir led to lower number of individuals with oral lesions (8 days after… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Systemic oral acyclovir vs placebo or no treatment

Duration and time of healing of extraoral lesions; development of new extraoral lesions · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir led to lower number of individuals who developed new extraoral lesions after… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Systemic oral acyclovir vs placebo or no treatment

Number of individuals with eating difficulties (8 days after administration); duration of eating difficulties · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir led to lower number of individuals with eating difficulties (8 days after… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Systemic oral acyclovir vs placebo or no treatment

Difficulty in drinking (number with drinking difficulties) · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir led to lower number of individuals with drinking difficulties (8 days after… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Systemic oral acyclovir vs placebo or no treatment

Number of individuals admitted to hospital after administration · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir showed no clear difference in number of individuals admitted to hospital after administration compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review