Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · ENT

No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 66.7%Moderate 0 · 0%High 0 · 0%

Adverse effects ‐ hepatic toxicity · chronic rhinosinusitis

Systemic antifungal showed no clear difference in adverse effects ‐ hepatic toxicity compared with placebo/no treatment (low certainty).

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
RR 3.35 [0.14, 78.6]
Studies not reported
Low

Gastrointestinal adverse events · chronic rhinosinusitis

Systemic antifungal showed no clear difference in adverse effects ‐ gastrointestinal disturbances compared with placebo/no treatment (low certainty).

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
RR 0.37 [0.04, 3.36]
Studies not reported
Low

Allergic adverse events · chronic rhinosinusitis

The review found no eligible studies for this question.

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Generic quality of life measures · chronic rhinosinusitis

The review found no eligible studies for this question.

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Health‐related quality of life (HRQL) · chronic rhinosinusitis

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Disease severity score · chronic rhinosinusitis

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low