Antibiotics vs no treatment or placebo on top of topical antiseptics
Suspected ototoxicity · schoolchildren with CSOM
1 finding from 1 review
- no estimate extracted1 study · 204 participantsVery low
Findings
What do systematic reviews say?
53 questions · 60 findings · 4 reviews
No studies found 18 · 30%GRADE not reported 14 · 23.3%Very low 21 · 35%Low 6 · 10%Moderate 1 · 1.7%High 0 · 0%
Antibiotics vs no treatment/placebo
Health‐related quality of life · children with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Antibiotics vs no treatment/placebo
Ear pain (otalgia) or discomfort or local irritation · children with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Antibiotics vs no treatment/placebo
Hearing · children with CSOM
1 finding from 1 review
- no estimate extracted1 study · 33 participantsVery low
Antibiotics vs no treatment/placebo
Serious complications ‐ during 6 months of · children with CSOM
1 finding from 1 review
- no estimate extracted1 study · 33 participantsVery low
Antibiotics vs no treatment/placebo
Suspected ototoxicity · children with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Antibiotics vs no treatment or placebo on top of topical antibiotics
Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with CSOM
Systemic antibiotics showed no clear difference in resolution of ear discharge ‐ measured at 1 to 2 weeks compared with no treatment or placebo on top of topical antibiotics (low certainty).
1 finding from 1 review
- RR 1.02 [0.93, 1.12]5 studies · 390 participantsLow
Antibiotics vs no treatment or placebo on top of topical antibiotics
Resolution of ear discharge ‐ measured after 4 weeks · people (of any age) with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Antibiotics (systemic) vs No antibiotics, placebo, or a different type of antibiotic
Outcome not reported · Patients (mainly children and young adults) with a history of dental trauma and a diagnosis of luxation (intrusion, extrusion, or lateral…
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth 2013 · Cochrane All outcomesMinimum 12 months follow-upTypes of antibiotics: the effect of using no antibiotics, a placebo or different types of antibiotics. Main results: No randomised or quasi-randomised controlled trials were found; no study was included in this review.0 studiesNo studies found
Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic
Prosthesis failure · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in prosthesis failure compared with no antibiotics or placebo; GRADE not reported.
1 finding from 1 review
- Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes3 to 5 monthsRR 0.44 [0.19, 1.00]5 studies · 1107 participantsGRADE not reported
Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic
Postoperative infection · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in postoperative infection compared with no antibiotics or placebo; GRADE not reported.
1 finding from 1 review
- Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes3 to 5 monthsRR 0.69 [0.36, 1.35]6 studies · 1162 participantsGRADE not reported
Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic
Implant failure · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) probably leads to lower implant failure compared with no antibiotics or placebo (moderate certainty).
1 finding from 1 review
- Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes4 monthsRR 0.33 [0.16, 0.67]6 studies · 1162 participantsModerate
Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic
Adverse events · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.
1 finding from 1 review
- Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes3 to 5 monthsRR 1.0 [0.06, 15.85]6 studies · 1162 participantsGRADE not reported
Systemic antibiotics without surgical intervention (with or without analgesics) vs Matched placebo without surgical intervention (with or without analgesics)
Outcome not reported · Adults with symptomatic apical periodontitis or acute apical abscess
The review found no eligible studies for this question.
1 finding from 1 review
- Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomesWe found no studies comparing systemic antibiotics versus a matched placebo provided without a surgical intervention.0 studiesNo studies found
Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling
Swelling (mean) · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
The review found no eligible studies for this question.
3 findings from 1 review
- Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes24 hoursNo data available for this outcome.0 studiesNo studies found
- Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes7 daysRR 0.50 [0.10, 2.56]1 study · 72 participantsLow
- Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes72 hoursNo data available for this outcome.0 studiesNo studies found
Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling
Pain at 24 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review
- Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes24 hoursThe median pain at 24 hours in the control group was 3 (range 0 to 10); the median pain at 24 hours in the intervention group was the same (median 3, range 0 to 8). P = 0.219 (Mann-Whitney U).1 study · 72 participantsLow
Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling
Pain at 48 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review
- Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes48 hoursMedian pain at 48 hours 1 (range 0 to 9) in the antibiotic group versus 2 (range 0 to 10) in the control group. P = 0.242 (Mann-Whitney U).1 study · 72 participantsGRADE not reported
Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling
Analgesic (painkiller) use · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
Single preoperative dose of systemic antibiotics (clindamycin 600… showed no clear difference in analgesic use compared with matched placebo, total chemo-mechanical debridement and root filling; GRADE not reported.
1 finding from 1 review
- Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes7 daysRR 0.87 [0.48, 1.55]1 study · 72 participantsGRADE not reported
Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling
Pain at 72 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review
- Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes72 hoursThe median pain at 72 hours in the control group was 0 (range 0 to 10); the median pain at 72 hours in the intervention group was the same (median 0, range 0 to 7). P = 0.116 (Mann-Whitney U).1 study · 72 participantsLow
Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling
Adverse effects · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review
- Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes7 daysNo adverse effects reported in the placebo group; 1 participant reported dizziness in the intervention group. 72 participants (1 study).1 study · 72 participantsLow