Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

45 questions · 52 findings · 2 reviews

No studies found 16 · 30.8%GRADE not reported 1 · 1.9%Very low 28 · 53.8%Low 5 · 9.6%Moderate 2 · 3.8%High 0 · 0%

Metformin vs megestrol

Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes regression of endometrial hyperplasia (with or without atypia) to… compared with megestrol (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Metformin + megestrol vs megestrol

Progression of endometrial hyperplasia to endometrial cancer · endometrial hyerplasia

It is very uncertain whether summary of findings table ‐ Metformin + megestrol changes progression of endometrial hyperplasia to endometrial cancer compared with megestrol (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Metformin + megestrol vs megestrol

Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyerplasia

Summary of findings table ‐ Metformin + megestrol may leads to higher regression of endometrial hyperplasia (with or without atypia) to… compared with megestrol (low certainty).

1 finding from 1 review

Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system

Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes regression of endometrial hyperplasia (with or without atypia) to… compared with levonorgestrel intrauterine system (very low certainty).

1 finding from 1 review

Metformin vs megestrol

Hysterectomy rate · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes hysterectomy rate compared with megestrol (very low certainty).

1 finding from 1 review

Metformin vs megestrol

Abnormal uterine bleeding · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes abnormal uterine bleeding compared with megestrol (very low certainty).

1 finding from 1 review

Metformin vs megestrol

Adverse effects during treatment ‐ not reported · endometrial hyperplasia

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system

Hysterectomy rate · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes hysterectomy rate compared with levonorgestrel intrauterine system (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system

Abnormal uterine bleeding · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes abnormal uterine bleeding compared with levonorgestrel intrauterine system (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system

Adverse effects during treatment ‐ all effects · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes adverse effects during treatment ‐ all effects compared with levonorgestrel intrauterine system (very low certainty).

1 finding from 1 review