Findings

What do systematic reviews say?

3 questions · 6 findings · 1 reviews

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 3 · 50%Low 1 · 16.7%Moderate 1 · 16.7%High 0 · 0%

Metformin vs diet and exercise or another antidiabetic drug

Intensive diet plus exercise · people at increased risk for developing type 2 diabetes

4 findings from 1 review

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 139 participants
Very low
Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 2400 participants
Very low
Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Show 1 more finding

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
RR 1.61 [0.5, 5.23]
4 studies · 2550 participants
Very low

Metformin vs diet and exercise or another antidiabetic drug

Intensive diet plus exercise Description: direct medical costs per participant · people at increased risk for developing type 2 diabetes

1 finding from 1 review

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 2400 participants
Low

Metformin vs diet and exercise or another antidiabetic drug

Intensive diet plus exercise Diagnostic criteria: 1 trial applied the WHO 1985 criteria (FPG < 7.8 mmol/L and 2‐hour glucose ≥ 7.8 mmol/L and < 11.1 mmol/L) (Fang 2004) · people at increased risk for developing type 2 diabetes

Summary of findings table for metformin showed no clear difference in intensive diet plus exercise Diagnostic criteria: 1 trial applied… compared with diet and exercise or another antidiabetic drug (moderate certainty).

1 finding from 1 review

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
RR 0.8 [0.47, 1.37]
7 studies · 2960 participants
Moderate