Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

14 questions · 14 findings · 1 reviews

No studies found 2 · 14.3%GRADE not reported 0 · 0%Very low 9 · 64.3%Low 1 · 7.1%Moderate 2 · 14.3%High 0 · 0%

Phenobarbital vs levetiracetam

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with EEG‐confirmed seizures

Summary of findings table ‐ Phenobarbital probably leads to higher proportion of infants who achieve seizure control after the first… compared with levetiracetam (moderate certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Mortality before hospital discharge · neonates with clinically diagnosed seizures

Summary of findings table ‐ Phenobarbital showed no clear difference in mortality before hospital discharge compared with levetiracetam (low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Need for mechanical ventilation · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes requirement of mechanical ventilation compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who develop sedation or drowsiness · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop sedation or drowsiness compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who develop epilepsy post‐discharge · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop epilepsy post discharge compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with EEG‐confirmed seizures

Summary of findings table ‐ Phenobarbital probably leads to higher proportion of infants who achieve seizure control after the maximal… compared with levetiracetam (moderate certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Mortality before hospital discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes mortality before hospital discharge compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Need for mechanical ventilation · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes requirement of mechanical ventilation compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who develop sedation or drowsiness · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop sedation or drowsiness compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who develop epilepsy post‐discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop epilepsy post‐discharge compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who achieve seizure control after first… compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who achieve seizure control after maximal… compared with levetiracetam (very low certainty).

1 finding from 1 review