What do systematic reviews say?

Phenobarbital vs phenytoin

It is very uncertain whether summary of findings table ‐ Phenobarbital changes mortality before hospital discharge compared with phenytoin (very low certainty).

• Anti‐seizure medications for neonates with seizures 2023 · Cochrane Headline outcomes only
  RR 1.33 [0.79, 2.26]
  2 studies · 179 participants
  Very low