Summary of findings table ‐ Intermittent PEG‐asparaginase treatment (8 doses, 1000 IU/m2, IM) vs continuous PEG‐asparaginase treatment (15 doses, 1000 IU/m2, IM)
Asparaginase‐associated toxicity · children and adolescents (< 18 years of age) with first‐line ALL
Summary of findings table ‐ Intermittent PEG‐asparaginase treatment… probably leads to lower asparaginase‐associated toxicity compared with continuous PEG‐asparaginase treatment (15 doses, 1000 IU/m2, IM) (moderate certainty).
1 finding from 1 review
- PEG‐asparaginase treatment regimens for acute lymphoblastic leukaemia in children: a network meta‐analysis 2023 · Cochrane Headline outcomes onlyRR 0.53 [0.35, 0.78]1 study · 625 participantsModerate