evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

31 questions · 32 findings · 1 reviews

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 13 · 40.6%GRADE not reported 0 · 0%Very low 6 · 18.8%Low 8 · 25%Moderate 2 · 6.3%High 3 · 9.4%

Summary of findings table ‐ Convalescent plasma vs standard plasma

Resolution of symptoms · outpatients withmild disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in symptom resolution‐ all initial symptoms resolved compared with standard plasma (low certainty).

2 findings from 1 review

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Clinical improvement: participants discharged from hospital ‐ not reported · individuals with moderate to severe disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in clinical improvement: participants discharged from hospital compared with placebo or standard care alone (high certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Grades 3 and 4 adverse events · individuals with moderate to severe disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in grades 3 and 4 adverse events compared with placebo or standard care alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Serious adverse events ‐ total · individuals with moderate to severe disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in serious adverse events ‐ total compared with placebo or standard care alone (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs standard plasma

All‐cause mortality at up to day 28 · individuals with moderate to severe disease

It is very uncertain whether summary of findings table ‐ Convalescent plasma changes all‐cause mortality at up to day 28 compared with standard plasma (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs standard plasma

Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28 · individuals with moderate to severe disease

It is very uncertain whether summary of findings table ‐ Convalescent plasma changes clinical worsening: need for invasive mechanical ventilation, or… compared with standard plasma (very low certainty).

1 finding from 1 review