What do systematic reviews say?

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

Summary of findings ‐ initiation of penicillin prophylaxis may leads to lower incidence of S pneumoniae infection Isolated bacterial infection compared with placebo (low certainty).

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  OR 0.37 [0.16, 0.86]
  2 studies · 457 participants
  Low

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

Summary of findings ‐ initiation of penicillin prophylaxis showed no clear difference in deaths compared with placebo (low certainty).

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  OR 0.11 [0.01, 2.11]
  2 studies · 457 participants
  Low

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 457 participants
  Low

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

The review found no eligible studies for this question.

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

The review found no eligible studies for this question.

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 215 participants
  Low