Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 66.7%Moderate 0 · 0%High 0 · 0%

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

Requirement of other courses of antibiotics · children with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

Incidence of S pneumoniae infection Isolated bacterial infection · children with SCD

Summary of findings ‐ initiation of penicillin prophylaxis may leads to lower incidence of S pneumoniae infection Isolated bacterial infection compared with placebo (low certainty).

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
OR 0.37 [0.16, 0.86]
2 studies · 457 participants
Low

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

Deaths · children with SCD

Summary of findings ‐ initiation of penicillin prophylaxis showed no clear difference in deaths compared with placebo (low certainty).

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
OR 0.11 [0.01, 2.11]
2 studies · 457 participants
Low

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

Adverse effects · children with SCD

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 457 participants
Low

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

Antibiotic‐resistant organisms isolated · children with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

Compliance with treatment · children with SCD

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 215 participants
Low