What do systematic reviews say?

Benzodiazepines (lorazepam) vs diazepam

Summary of findings ‐ Lorazepam showed no clear difference in seizure cessation compared with diazepam (low certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 1.08 [0.98, 1.2]
  3 studies · 439 participants
  Low

Benzodiazepines (lorazepam) vs diazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  Moderate

Benzodiazepines (lorazepam) vs diazepam

Summary of findings ‐ Lorazepam probably leads to lower incidence of respiratory depression compared with diazepam (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.72 [0.55, 0.93]
  3 studies · 439 participants
  Moderate

Benzodiazepines (lorazepam) vs diazepam

Summary of findings ‐ Lorazepam showed no clear difference in additional drugs required to terminate the seizure: additional dose… compared with diazepam (low certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.88 [0.64, 1.2]
  3 studies · 439 participants
  Low

Benzodiazepines (lorazepam) vs diazepam

Summary of findings ‐ Lorazepam showed no clear difference in seizure recurrence within 24 hours compared with diazepam (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.86 [0.61, 1.2]
  3 studies · 439 participants
  Moderate

Benzodiazepines (lorazepam) vs diazepam

Summary of findings ‐ Lorazepam may leads to lower incidence of admissions to the ICU compared with diazepam (low certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.15 [0.02, 0.98]
  1 study · 86 participants
  Low

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Summary of findings ‐ Intravenous lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 1 [0.98, 1.02]
  1 study · 178 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 178 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Summary of findings ‐ Intravenous lorazepam showed no clear difference in incidence of respiratory depression compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.78 [0.22, 2.82]
  1 study · 178 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Summary of findings ‐ Intravenous lorazepam showed no clear difference in additional drugs required to stop the seizure compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.42 [0.17, 1.04]
  1 study · 178 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 178 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found