Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Benzodiazepines (lorazepam) vs diazepam

Seizure freedom · Children with acute tonic‐clonic seizures

Summary of findings ‐ Lorazepam showed no clear difference in seizure cessation compared with diazepam (low certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 1.08 [0.98, 1.2]
3 studies · 439 participants
Low

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Seizure cessation: within 10 minutes · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 1 [0.98, 1.02]
1 study · 178 participants
Moderate