What do systematic reviews say?

Summary of findings ‐ Lanthanum vs calcium

Summary of findings ‐ Lanthanum showed no clear difference in death (all causes) compared with calcium (low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 0.76 [0.18, 3.11]
  6 studies · 505 participants
  Low

Summary of findings ‐ Lanthanum vs calcium

The review found no eligible studies for this question.

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Lanthanum vs calcium

Summary of findings ‐ Lanthanum may leads to lower hypercalcaemia compared with calcium (low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 0.16 [0.06, 0.43]
  8 studies · 1347 participants
  Low

Summary of findings ‐ Lanthanum vs calcium

Summary of findings ‐ Lanthanum showed no clear difference in nausea compared with calcium (low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 1.65 [0.95, 2.89]
  5 studies · 1191 participants
  Low

Summary of findings ‐ Lanthanum vs calcium

It is very uncertain whether summary of findings ‐ Lanthanum changes vomiting compared with calcium (very low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 3.88 [0.48, 31.7]
  2 studies · 1058 participants
  Very low

Summary of findings ‐ Lanthanum vs calcium

Summary of findings ‐ Lanthanum showed no clear difference in constipation compared with calcium (low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 0.79 [0.5, 1.26]
  5 studies · 1213 participants
  Low

Summary of findings ‐ Lanthanum vs calcium

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 400 participants
  Very low

Summary of findings ‐ Lanthanum vs calcium

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 42 participants
  Very low

Summary of findings ‐ Lanthanum vs placebo or usual care

The review found no eligible studies for this question.

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Lanthanum vs placebo or usual care

Summary of findings: Lanthanum may leads to higher nausea compared with placebo/usual care (low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 3.72 [1.36, 10.18]
  4 studies · 383 participants
  Low

Summary of findings ‐ Lanthanum vs placebo or usual care

It is very uncertain whether summary of findings: Lanthanum changes vomiting compared with placebo/usual care (very low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 2.76 [0.41, 18.63]
  3 studies · 261 participants
  Very low

Summary of findings ‐ Lanthanum vs placebo or usual care

Summary of findings: Lanthanum probably leads to higher constipation compared with placebo/usual care (moderate certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 2.98 [1.21, 7.3]
  4 studies · 299 participants
  Moderate

Summary of findings ‐ Lanthanum vs placebo or usual care

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 171 participants
  Low

Summary of findings ‐ Lanthanum vs placebo or usual care

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 38 participants
  Very low

Summary of findings ‐ Lanthanum vs placebo or usual care

It is very uncertain whether summary of findings: Lanthanum changes death (all causes) compared with placebo/usual care (very low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 1.63 [0.07, 37.12]
  3 studies · 214 participants
  Very low