Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 33.3%High 2 · 33.3%

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

Seizure freedom · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intranasal midazolam showed no clear difference in seizure cessation compared with intravenous diazepam (moderate certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.98 [0.91, 1.06]
2 studies · 122 participants
Moderate

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 122 participants
Moderate

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

Incidence of respiratory depression · Children with acute tonic‐clonic seizures

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 122 participants
High

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
High