Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 12 findings · 1 reviews · Epilepsy

No studies found 5 · 41.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 25%Moderate 2 · 16.7%High 2 · 16.7%

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

Seizure freedom · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intranasal midazolam showed no clear difference in seizure cessation compared with intravenous diazepam (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Intranasal midazolam vs rectal diazepam

Seizure cessation: within 10 minutes · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intranasal midazolam showed no clear difference in seizure cessation: within 10 minutes compared with rectal diazepam (low certainty).

1 finding from 1 review

Summary of findings ‐ Intranasal midazolam vs rectal diazepam

Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intranasal midazolam showed no clear difference in additional drugs required to stop the seizure compared with rectal diazepam (low certainty).

1 finding from 1 review