Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

Additional drugs required to terminate the seizure: 2 or more additional anticonvulsants required · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intranasal lorazepam may leads to lower additional drugs required to terminate the seizure: 2 or more… compared with intramuscular paraldehyde (low certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.38 [0.18, 0.81]
1 study · 160 participants
Low

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intranasal lorazepam showed no clear difference in seizure recurrence within 24 hours compared with intramuscular paraldehyde (low certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.73 [0.31, 1.71]
1 study · 160 participants
Low

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

Seizure cessation: within 10 minutes · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intranasal lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intramuscular paraldehyde (moderate certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 1.22 [0.99, 1.52]
1 study · 160 participants
Moderate

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

Incidence of respiratory depression · Children with acute tonic‐clonic seizures

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 160 participants
Low