Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Epilepsy

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 50%Low 2 · 33.3%Moderate 1 · 16.7%High 0 · 0%

Summary of findings ‐ Intramuscular midazolam vs intravenous diazepam

Seizure freedom · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intramuscular midazolam showed no clear difference in seizure cessation compared with intravenous diazepam (low certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.97 [0.87, 1.09]
2 studies · 105 participants
Low

Summary of findings ‐ Intramuscular midazolam vs intravenous diazepam

Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 105 participants
Very low

Summary of findings ‐ Intramuscular midazolam vs intravenous diazepam

Incidence of respiratory depression · Children with acute tonic‐clonic seizures

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 105 participants
Low

Summary of findings ‐ Intramuscular midazolam vs intravenous diazepam

Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures

It is very uncertain whether summary of findings ‐ Intramuscular midazolam changes additional drugs required to terminate the seizure compared with intravenous diazepam (very low certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 1.34 [0.35, 5.13]
2 studies · 105 participants
Very low

Summary of findings ‐ Intramuscular midazolam vs intravenous diazepam

Seizure recurrence within 24 hours: within one hour · Children with acute tonic‐clonic seizures

It is very uncertain whether summary of findings ‐ Intramuscular midazolam changes seizure recurrence within 24 hours: within one hour compared with intravenous diazepam (very low certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.85 [0.27, 2.62]
1 study · 24 participants
Very low

Summary of findings ‐ Intramuscular midazolam vs intravenous diazepam

Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 81 participants
Moderate