Hydroxyurea vs placebo
Adverse events or toxicity: differences in rates of specific adverse events · people with sickle cell disease
1 finding from 1 review
- no estimate extracted5 studies · 784 participantsLow
Findings
What do systematic reviews say?
28 questions · 28 findings · 1 reviews
No studies found 6 · 21.4%GRADE not reported 0 · 0%Very low 9 · 32.1%Low 6 · 21.4%Moderate 7 · 25%High 0 · 0%
Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation
All‐cause mortality · adults and children with sickle cell disease and an increased risk of stroke
Summary of findings ‐ Hydroxyurea and phlebotomy showed no clear difference in death during the study (all deaths) compared with transfusion and chelation (low certainty).
1 finding from 1 review
- RR 0.99 [0.06, 15.42]2 studies · 254 participantsLow
Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation
Measures of HbF · adults and children with sickle cell disease and an increased risk of stroke
1 finding from 1 review
- no estimate extracted2 studies · 254 participantsModerate
Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation
Measures of ANC · adults and children with sickle cell disease and an increased risk of stroke
1 finding from 1 review
- no estimate extracted2 studies · 254 participantsModerate
Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation
Quality of life · adults and children with sickle cell disease and an increased risk of stroke
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation
Adverse events or toxicity: differences in rates of specific adverse events · adults and children with sickle cell disease and an increased risk of stroke
1 finding from 1 review
- no estimate extracted2 studies · 254 participantsLow
Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation
Pain alteration: proportion experiencing serious VOC or sickle‐related pain events · adults and children with sickle cell disease and an increased risk of stroke
Summary of findings ‐ Hydroxyurea and phlebotomy may leads to higher pain alteration: proportion experiencing serious VOC or… compared with transfusion and chelation (low certainty).
1 finding from 1 review
- RR 3.37 [1.59, 7.11]2 studies · 254 participantsLow
Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation
Life‐threatening illness · adults and children with sickle cell disease and an increased risk of stroke
1 finding from 1 review
- no estimate extracted2 studies · 254 participantsModerate