Hydroxyurea vs no hydroxyurea
Death during the study · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 44 participantsVery low
Findings
What do systematic reviews say?
4 questions · 4 findings · 1 reviews
No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 1 · 25%Moderate 1 · 25%High 0 · 0%
Hydroxyurea vs observation
Death during the study · adults and children with sickle cell disease and an increased risk of stroke
1 finding from 1 review
- no estimate extracted1 study · 22 participantsVery low
Hydroxyurea vs placebo
All‐cause mortality · people with sickle cell disease
Summary of findings ‐ Hydroxyurea showed no clear difference in death during the study (all deaths) compared with placebo (moderate certainty).
1 finding from 1 review · compare the 2 reviews
- RR 0.65 [0.19, 2.27]5 studies · 784 participantsModerate
Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation
All‐cause mortality · adults and children with sickle cell disease and an increased risk of stroke
Summary of findings ‐ Hydroxyurea and phlebotomy showed no clear difference in death during the study (all deaths) compared with transfusion and chelation (low certainty).
1 finding from 1 review
- RR 0.99 [0.06, 15.42]2 studies · 254 participantsLow