Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Headline outcomes only

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No studies found 3 · 42.9%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 1 · 14.3%High 2 · 28.6%

Summary of findings ‐ Buccal midazolam vs rectal diazepam

Additional drugs required to stop the seizure: intravenous lorazepam required · Children with acute tonic‐clonic seizures

Summary of findings ‐ Buccal midazolam may leads to lower additional drugs required to stop the seizure: intravenous lorazepam… compared with rectal diazepam (low certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.58 [0.42, 0.79]
1 study · 177 participants
Low

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

Seizure freedom · Children with acute tonic‐clonic seizures

Summary of findings ‐ Buccal midazolam showed no clear difference in seizure cessation compared with intravenous diazepam (high certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.91 [0.8, 1.03]
1 study · 120 participants
High

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 120 participants
Moderate

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

Incidence of respiratory depression · Children with acute tonic‐clonic seizures

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 120 participants
High

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found