What do systematic reviews say?

HRQoL ‐ all domains (change from baseline) Scale: age‐appropriate versions of the CFQ‐R questionnaire · adults, children and young people with CF

Lung function: FEV1 mL (change from baseline) · adults, children and young people with CF

FEV1 % predicted: absolute change from baseline · adults, children and young people with CF

FVC · adults, children and young people with CF

Lung function: FEF25‐75 mL/s (change from baseline) · adults, children and young people with CF

Adverse events relating to treatment Scale: mild, moderate, severe and total · adults, children and young people with CF