Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

32 questions · 35 findings · 1 reviews

No studies found 18 · 51.4%GRADE not reported 1 · 2.9%Very low 7 · 20%Low 8 · 22.9%Moderate 1 · 2.9%High 0 · 0%

Summary of findings: pioglitazone monotherapy vs placebo

Cardiovascular mortality · people at increased risk for developing type 2 diabetes

It is very uncertain whether summary of findings: pioglitazone monotherapy changes cardiovascular mortality (N) compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs placebo

Non‐fatal myocardial infarction/stroke · people at increased risk for developing type 2 diabetes

It is very uncertain whether summary of findings: pioglitazone monotherapy changes non‐fatal myocardial infarction/stroke (N) compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs no intervention

All‐cause mortality · people at increased risk for developing type 2 diabetes

It is very uncertain whether summary of findings: pioglitazone monotherapy changes all‐cause mortality (N) compared with no intervention (very low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs no intervention

Incidence of T2DM (N) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy probably leads to lower incidence of T2DM (N) Diagnostic criteria: 9 studies applied the WHO… compared with no intervention (moderate certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs no intervention

Serious adverse events (N) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy showed no clear difference in serious adverse events (N) compared with no intervention (low certainty).

1 finding from 1 review