Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Kidney and Transplant

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No studies found 1 · 12.5%GRADE not reported 0 · 0%Very low 6 · 75%Low 1 · 12.5%Moderate 0 · 0%High 0 · 0%

Summary of findings: Sevelamer vs placebo or usual care

Death (all causes) · people with CKD

It is very uncertain whether summary of findings: Sevelamer changes death (all causes) compared with placebo/usual care (very low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 2.16 [0.2, 22.8]
3 studies · 248 participants
Very low

Summary of findings: Sevelamer vs placebo or usual care

Cardiovascular mortality · people with CKD

The review found no eligible studies for this question.

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Sevelamer vs placebo or usual care

Hypercalcaemia · people with CKD

It is very uncertain whether summary of findings: Sevelamer changes hypercalcaemia compared with placebo/usual care (very low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 1.9 [0.12, 29.32]
1 study · 42 participants
Very low

Summary of findings: Sevelamer vs placebo or usual care

Nausea · people with CKD

It is very uncertain whether summary of findings: Sevelamer changes nausea compared with placebo/usual care (very low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 1.27 [0.07, 22.42]
3 studies · 370 participants
Very low

Summary of findings: Sevelamer vs placebo or usual care

Vomiting · people with CKD

It is very uncertain whether summary of findings: Sevelamer changes vomiting compared with placebo/usual care (very low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 2.09 [0.26, 16.57]
2 studies · 165 participants
Very low

Summary of findings: Sevelamer vs placebo or usual care

Constipation · people with CKD

Summary of findings: Sevelamer may leads to higher constipation compared with placebo/usual care (low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 6.92 [2.24, 21.38]
4 studies · 430 participants
Low

Summary of findings: Sevelamer vs placebo or usual care

Serum phosphate level · people with CKD

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 483 participants
Very low

Summary of findings: Sevelamer vs placebo or usual care

Coronary artery calcification score · people with CKD

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 115 participants
Very low