Findings

What do systematic reviews say?

42 questions · 42 findings · 1 reviews

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No studies found 24 · 57.1%GRADE not reported 0 · 0%Very low 12 · 28.6%Low 4 · 9.5%Moderate 2 · 4.8%High 0 · 0%

Summary of findings: ECM vs TPE

Adverse events · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs TPE

Pulmonary exacerbations · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs other enteric‐coated preparations

Change in weight (kg) · children with cystic fibrosis

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 56 participants
Very low

Summary of findings: ECM vs other enteric‐coated preparations

Change in height · children with cystic fibrosis

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 45 participants
Very low

Summary of findings: ECM vs other enteric‐coated preparations

Change in BMI · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs other enteric‐coated preparations

Frequency of bowel symptoms: stool frequency · children with cystic fibrosis

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 56 participants
Very low

Summary of findings: ECM vs NECT plus cimetidine

Abdominal pain frequency or change in frequency · adults with cystic fibrosis

It is very uncertain whether summary of findings: ECM changes frequency in bowel symptoms: abdominal pain (% of days affected) compared with NECT plus cimetidine (very low certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Summary of findings: ECM vs other enteric‐coated preparations

CFA: fat absorption · children with cystic fibrosis

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 56 participants
Very low

Summary of findings: ECM vs other enteric‐coated preparations

Adverse events · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs other enteric‐coated preparations

Pulmonary exacerbations · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs NECT plus cimetidine

CFA: change in FFE (g/day) · adults with cystic fibrosis

Summary of findings: ECM showed no clear difference in CFA: change in FFE (g/day) compared with NECT plus cimetidine (low certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Low

Summary of findings: ECM vs NECT plus cimetidine

Adverse events · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs NECT plus cimetidine

Pulmonary exacerbations · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs ECT

Change in weight (kg) · adults and children with cystic fibrosis

It is very uncertain whether summary of findings: ECM changes change in weight (kg) compared with ECT (very low certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
MD 0.32
2 studies · 41 participants
Very low

Summary of findings: ECM vs ECT

Change in height · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs a different ECM

Change in weight (kg) · adults and children with cystic fibrosis

Summary of findings: ECM (Creon®) showed no clear difference in change in weight (kg) compared with a different ECM (moderate certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
MD 0
1 study · 83 participants
Moderate

Summary of findings: ECM vs a different ECM

Change in height · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs a different ECM

Change in BMI · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs a different ECM

Abdominal pain frequency or change in frequency · adults and children with cystic fibrosis

Summary of findings: ECM (Creon®) showed no clear difference in frequency of bowel symptoms: proportion of days with abdominal pain compared with a different ECM (low certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
MD 0
1 study · 83 participants
Low

Summary of findings: ECM vs a different ECM

CFA: CFA (%) · adults and children with cystic fibrosis

Summary of findings: ECM (Creon®) showed no clear difference in CFA: CFA (%) compared with a different ECM (moderate certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
MD 1.35
2 studies · 110 participants
Moderate