Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Kidney and Transplant

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 1 · 14.3%Moderate 3 · 42.9%High 2 · 28.6%

Major cardiovascular event Physicians · Adults with chronic kidney disease not requiring dialysis

Statin therapy leads to lower major cardiovascular events (MACE) compared with placebo or standard of care (high certainty).

1 finding from 1 review

Death · Adults with chronic kidney disease not requiring dialysis

Statin therapy leads to lower death compared with placebo or standard of care (high certainty).

1 finding from 1 review

Rhabdomyolysis · Adults with chronic kidney disease not requiring dialysis

It is very uncertain whether statin therapy changes rhabdomyolysis compared with placebo or standard of care (very low certainty).

1 finding from 1 review

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis 2023 · Cochrane Headline outcomes only
RR 3.07 [0.13, 75.37]
2 studies · 2618 participants
Very low

Myocardial infarction · Adults with chronic kidney disease not requiring dialysis

Statin therapy probably leads to lower myocardial infarction compared with placebo or standard of care (moderate certainty).

1 finding from 1 review

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis 2023 · Cochrane Headline outcomes only
RR 0.55 [0.42, 0.73]
10 studies · 9475 participants
Moderate

Stroke · Adults with chronic kidney disease not requiring dialysis

Statin therapy showed no clear difference in stroke compared with placebo or standard of care (moderate certainty).

1 finding from 1 review

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis 2023 · Cochrane Headline outcomes only
RR 0.64 [0.37, 1.08]
7 studies · 9158 participants
Moderate

Kidney failure · Adults with chronic kidney disease not requiring dialysis

Statin therapy showed no clear difference in kidney failure compared with placebo or standard of care (moderate certainty).

1 finding from 1 review

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis 2023 · Cochrane Headline outcomes only
RR 0.98 [0.91, 1.05]
3 studies · 6704 participants
Moderate

Heart failure hospitalisation (RR) · Adults with chronic kidney disease not requiring dialysis

Statin therapy showed no clear difference in hospitalisation due to heart failure compared with placebo or standard of care (low certainty).

1 finding from 1 review