What do systematic reviews say?

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

It is very uncertain whether standard intravenous acetylcysteine regimen (20.5 hour) changes hepatotoxicity compared with shorter intravenous acetylcysteine regimen (12 hour) (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.67 [0.11, 4.08]
  1 study · 202 participants
  Very low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics from 0‐2 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.3 [0.17, 0.53]
  1 study · 217 participants
  Low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics 0‐12 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.4 [0.22, 0.75]
  1 study · 203 participants
  Low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower anaphylactoid symptoms compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.39 [0.21, 0.7]
  1 study · 208 participants
  Low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 222 participants
  Very low