Findings

What do systematic reviews say?

9 questions · 9 findings · 1 reviews · Headline outcomes only

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No studies found 4 · 44.4%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 44.4%Moderate 1 · 11.1%High 0 · 0%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Sodium thiosulfate vs no otoprotective intervention · Ototoxicity according to Brock criteria with intravenous platinum (combined asymptomatic and symptomatic disease)
  Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
  RR 0.52 [0.33, 0.81]
  1 study · 101 participants
  Moderate
Direct match · question page
- Sodium thiosulfate vs no otoprotective intervention · Quality of life
  Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
Direct match · question page
- Sodium thiosulfate vs no otoprotective intervention · Event‐free survival with intravenous platinum (i.e. number of participants with disease progression, disease relapse, second primary cancer or death)
  Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
  HR 0.85 [0.37, 1.94]
  1 study · 109 participants
  Low
Direct match · question page
- Sodium thiosulfate vs no otoprotective intervention · Adverse effects other than ototoxicity (≥ grade 3 according to NCICTCAEv3 criteria) with intravenous platinum
  Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 109 participants
  Low
Direct match · question page
- Sodium thiosulfate vs no otoprotective intervention · Tumour response with intravenous platinum (complete and partial remission)
  Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
  RR 1.06 [0.98, 1.15]
  1 study · 108 participants
  Low

Sodium thiosulfate vs no otoprotective intervention

Ototoxicity according to Brock criteria with intravenous platinum (combined asymptomatic and symptomatic disease) · children with cancer treated with platinum‐based therapy

Sodium thiosulfate probably leads to lower ototoxicity according to Brock criteria with intravenous platinum… compared with no otoprotective intervention (moderate certainty).

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
RR 0.52 [0.33, 0.81]
1 study · 101 participants
Moderate

Sodium thiosulfate vs no otoprotective intervention

Overall survival with intravenous platinum (i.e. mortality/number of participants deceased) · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in overall survival with intravenous platinum (i.e. mortality/number of… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
HR 0.43 [0.03, 5.85]
1 study · 109 participants
Low

Sodium thiosulfate vs no otoprotective intervention

Event‐free survival · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in event‐free survival with intravenous platinum (i.e. number of… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
HR 0.85 [0.37, 1.94]
1 study · 109 participants
Low

Sodium thiosulfate vs no otoprotective intervention

Tumour response with intravenous platinum (complete and partial remission) · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in tumour response with intravenous platinum (complete and partial… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
RR 1.06 [0.98, 1.15]
1 study · 108 participants
Low

Sodium thiosulfate vs no otoprotective intervention

Adverse effects other than ototoxicity (≥ grade 3 according to NCICTCAEv3 criteria) with intravenous platinum · children with cancer treated with platinum‐based therapy

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 109 participants
Low

Sodium thiosulfate vs no otoprotective intervention

Survival · children with cancer treated with platinum‐based therapy

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sodium thiosulfate vs no otoprotective intervention

Tumour response · children with cancer treated with platinum‐based therapy

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sodium thiosulfate vs no otoprotective intervention

Quality of life · children with cancer treated with platinum‐based therapy

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sodium thiosulfate vs no otoprotective intervention

Quality of life ‐ not reported · children with cancer treated with platinum‐based therapy

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found