Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 60%High 2 · 40%

Single inhaler therapy vs fixed dose ICS

Withdrawals due to adverse events · adults with asthma not well controlled on ICS

Single inhaler therapy leads to lower discontinuation due to adverse events compared with fixed dose ICS (high certainty).

1 finding from 1 review

Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including… 2013 · Cochrane Headline outcomes only
OR 0.57 [0.35, 0.93]
2 studies · 2586 participants
High

Single inhaler therapy vs fixed dose ICS

Hospital admissions due to exacerbations: number of participants · adults with asthma not well controlled on ICS

Single inhaler therapy showed no clear difference in patients with exacerbations causing hospitalisation compared with fixed dose ICS (moderate certainty).

1 finding from 1 review

Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including… 2013 · Cochrane Headline outcomes only
OR 0.56 [0.28, 1.09]
3 studies · 4209 participants
Moderate

Single inhaler therapy vs fixed dose ICS

Rate of exacerbations requiring systemic corticosteroids · adults with asthma not well controlled on ICS

Single inhaler therapy leads to lower patients with exacerbations treated with oral steroids compared with fixed dose ICS (high certainty).

1 finding from 1 review

Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including… 2013 · Cochrane Headline outcomes only
OR 0.54 [0.45, 0.64]
4 studies · 4280 participants
High

Single inhaler therapy vs fixed dose ICS

Fatal serious adverse events · adults with asthma not well controlled on ICS

Single inhaler therapy showed no clear difference in fatal serious adverse events compared with fixed dose ICS (moderate certainty).

1 finding from 1 review

Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including… 2013 · Cochrane Headline outcomes only
OR 0.37 [0.05, 2.62]
3 studies · 4209 participants
Moderate

Single inhaler therapy vs fixed dose ICS

Non‐fatal serious adverse events · adults with asthma not well controlled on ICS

Single inhaler therapy showed no clear difference in serious adverse events (non‐fatal) compared with fixed dose ICS (moderate certainty).

1 finding from 1 review

Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including… 2013 · Cochrane Headline outcomes only
OR 0.97 [0.73, 1.29]
3 studies · 4209 participants
Moderate