Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

108 questions · 125 findings · 5 reviews

No studies found 36 · 28.8%GRADE not reported 44 · 35.2%Very low 34 · 27.2%Low 6 · 4.8%Moderate 5 · 4%High 0 · 0%

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Primary caries prevention · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

1 finding from 1 review

Silver diamine fluoride (SDF) vs Chlorhexidine varnish

Primary caries prevention · Children and adults (with or without carious lesions)

It is very uncertain whether silver diamine fluoride (SDF) changes primary caries prevention compared with chlorhexidine varnish (very low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Restoration (restorative treatment)

Dental pain or sensitivity · Children and adults (with or without carious lesions)

It is very uncertain whether silver diamine fluoride (SDF) changes dental pain or sensitivity compared with restoration (restorative treatment) (very low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish

Caries arrest · Children and adults (with or without carious lesions)

It is very uncertain whether silver diamine fluoride (SDF) changes caries arrest compared with glass ionomer cement (GIC) plus fluoride varnish (very low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Fluoride varnish

Caries arrest · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

3 findings from 1 review

Silver diamine fluoride (SDF) vs Silver nitrate plus fluoride varnish

Caries arrest · Children and adults (with or without carious lesions)

Silver diamine fluoride (SDF) showed no clear difference in caries arrest compared with silver nitrate plus fluoride varnish (low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Caries arrest · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

2 findings from 1 review

SDF plus potassium iodide vs Split into two contrasts: (1) TCS paste (arrest 100%); (2) CPP-ACP (arrest 100%); SDF+KI arrest 54.8% at 24 months, p<.001

Caries arrest · Patients with early enamel carious lesions on permanent molars

SDF plus potassium iodide arrested 54.8% of early enamel lesions at 24 months; no pooled estimate or GRADE rating was reported.

1 finding from 1 review

38% SDF (every 6 months) vs no treatment

Inactive (arrested) carious lesions on permanent first molars · Children with dental caries in permanent (first) molars

Six-monthly SDF produced significantly more inactive (arrested) lesions than no treatment in children's permanent molars (0.3 vs 0.1; p<0.05; ungraded).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Any (current minimally invasive techniques)

Not applicable (no eligible studies) · Adults with coronal (crown) dental caries in permanent teeth

No eligible studies assessed SDF for coronal caries in adults; this is an evidence gap identified by the review.

1 finding from 1 review

38% SDF (indirect pulp capping) vs Resin-modified glass ionomer cement (RMGIC)

Secondary prevention of caries · children with deep occlusal carious lesions in permanent molars

No significant difference in secondary caries prevention was reported; no effect estimate or GRADE rating was reported.

1 finding from 1 review

Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations)

Caries arrest · Children and adults (with or without carious lesions)

Silver diamine fluoride (SDF) plus fluoride varnish showed no clear difference in caries arrest compared with sealants plus fluoride varnish (with or without restorations) (low certainty).

1 finding from 1 review